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Structure of 656-46-2
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This difluorinated benzo[d][1,3]dioxole carboxylic acid integrates a rigid, electron-deficient aromatic core with enhanced metabolic stability. The ortho-fluorine substitution pattern imparts favorable lipophilicity and resistance to enzymatic degradation, making it a valuable scaffold for bioactive molecule design.
2,2-Difluorobenzo[d][1,3]dioxole-5-carboxylic acid serves as a versatile building block for the synthesis of fluorinated heterocyclic scaffolds. Its carboxylic acid functionality enables straightforward derivatization via amide, ester, or acyl chloride formation, while the ortho-difluoro substitution enhances metabolic stability and modulates electronic properties. The benzo[d][1,3]dioxole core provides structural rigidity and favorable lipophilicity, making it valuable in medicinal chemistry campaigns targeting CNS and kinase-directed therapeutics. The compound exhibits good bench stability and is compatible with standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: