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Structure of 65753-47-1
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2-Chloro-3-(trifluoromethyl)pyridine features a trifluoromethyl group at the 3-position and a chlorine atom at the 2-position on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This configuration enhances reactivity in cross-coupling processes and facilitates incorporation into bioactive molecules. The compound exhibits bench-stable handling characteristics and compatibility with standard synthetic protocols.
2-Chloro-3-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its electrophilic chlorine atom. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridine core provides a rigid scaffold for targeted molecular design. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient route optimization in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS05,GHS06,GHS08
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Signal Word : Danger
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UN#: 2928
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Class : 6.1 (8)
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Packing Group : Ⅱ
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Hazard Statements : H301+H311-H314-H372-H412
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Precautionary Statements : P260-P264-P270-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P363-P405-P501
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Lot numbers can be found on the outside label of a product: