4-Chlorobenzo[b]thiophene

Name: 4-Chlorobenzo[b]thiophene
Brand: ChemScene
Availability: InStock
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CAS No. 66490-33-3
Cat. No. CS-0097337
Purity≥97%
MDL No.MFCD18451627

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 66490-33-3

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Description

4-Chlorobenzo[b]thiophene features a fused benzothiophene core with a chloro substituent at the 4-position, delivering enhanced electron-withdrawal and improved metabolic stability. This structural motif integrates readily into pharmaceutical scaffolds and advanced materials, offering robust performance under standard synthetic conditions.

Application

4-Chlorobenzo[b]thiophene serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient transition-metal-catalyzed cross-coupling reactions. Its chlorine substituent facilitates Pd- or Ni-mediated functionalization, while the fused thiophene core provides robust stability and favorable electronic properties for downstream scaffold elaboration. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it ideal for iterative synthesis workflows.

General Information

CAS No. 66490-33-3
Cat. No. CS-0097337
Purity ≥97%
MDL No. MFCD18451627
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClS
Molecular Weight 168.64
Synonym(s) 4-Chlorobenzothiophene
SMILES ClC1=C(C=CS2)C2=CC=C1

Computational Chemistry Data

TPSA 0
LogP 3.5547
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiophene compounds

Key Words

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4-Chlorobenzo[b]thiophene

CAS No. 66490-33-3

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