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CS-W001157 4
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Methyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

  • CAS No. 66494-26-6

  • Cat. No. CS-M3284
  • Molecule weight215.25
  • Purity≥97%
  • MDL No.MFCD11520021

*For research and further manufacturing use only, not for direct human use.

Methyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate|CS-M3284

Structure of 66494-26-6

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General Information

  • CAS No. 66494-26-6
  • Cat. No. CS-M3284
  • Purity ≥97%
  • MDL No. MFCD11520021
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄
  • Molecular Weight 215.25
  • Synonym(s) Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate
  • SMILES O=C(OC)C1(NC(OC(C)(C)C)=O)CC1

Description

Methyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate features a cyclopropane ring bearing both a carbamate-protected amine and an ester group, enabling direct incorporation into peptide backbones. The tert-butyl protection ensures stability during synthetic manipulations, while the strained cyclopropane geometry imparts conformational rigidity useful in bioactive molecule design.

Application

Methyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate serves as a versatile building block in synthetic organic chemistry, enabling the construction of cyclopropyl-containing scaffolds prevalent in bioactive molecules. The Boc-protected amine and ester functionalities offer orthogonal reactivity, facilitating sequential transformations under standard conditions. Bench-stable and readily purified by flash chromatography, it supports efficient access to substituted cyclopropane derivatives via selective deprotection and functionalization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.63
  • LogP   1.2167
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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