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CS-W001157 4
Total: USD 88.00

2-Chloro-6-fluorobenzonitrile

  • CAS No. 668-45-1

  • Cat. No. CS-W020582
  • Purity≥98%
  • MDL No.MFCD00001780
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-fluorobenzonitrile|CS-W020582

Structure of 668-45-1

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Description

2-Chloro-6-fluorobenzonitrile features a dual halogen substitution pattern that enhances reactivity in cross-coupling processes. The electron-deficient aromatic ring pairs effectively with nucleophilic partners, while the nitrile group provides a versatile handle for downstream functionalization. This compound serves as a key intermediate in pharmaceutical and agrochemical synthesis.

Application

2-Chloro-6-fluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the ortho position relative to the nitrile group. Its dual halogen substituents facilitate palladium-catalyzed cross-coupling reactions, while the nitrile moiety offers compatibility with nucleophilic additions and cyclizations. The compound exhibits good bench stability and is readily purified by distillation or recrystallization, supporting scalable applications in complex molecule assembly.

General Information

  • CAS No. 668-45-1
  • Cat. No. CS-W020582
  • Purity ≥98%
  • MDL No. MFCD00001780
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClFN
  • Molecular Weight 155.56
  • Synonym(s) LABOTEST-BB LT00159627
  • SMILES N#CC1=C(F)C=CC=C1Cl

Computational Chemistry Data

  • TPSA   23.79
  • LogP   2.35078
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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