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CS-W001157 4
Total: USD 88.00

4-Hydroxy-6-methylnicotinic acid

  • CAS No. 67367-33-3

  • Cat. No. CS-W003138
  • Molecule weight153.14
  • Purity≥98%
  • MDL No.MFCD04038153

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-6-methylnicotinic acid|CS-W003138

Structure of 67367-33-3

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General Information

  • CAS No. 67367-33-3
  • Cat. No. CS-W003138
  • Purity ≥98%
  • MDL No. MFCD04038153
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid
  • SMILES Cc1cc(O)c(cn1)C(=O)O

Application

4-Hydroxy-6-methylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted nicotinamide derivatives and heterocyclic scaffolds. Its ortho-hydroxyl and methyl groups provide defined regiochemistry for downstream functionalization, while the carboxylic acid facilitates direct amidation or esterification. The compound exhibits good bench stability and is compatible with standard purification techniques, supporting efficient integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • 3-((Dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione|CS-1091079
      33821-61-3
    • ~74%
    • In-stock
      4-Hydroxy-6-methylnicotinic acid|CS-W003138
      67367-33-3

    References

    • Law, Ga-Lai; Man, Cornelia; Parker, David; Walton, James W. Chemical Communications, 2010 , vol. 46, # 14 p. 2391 - 2393
  • Route2
    • In-stock
      2-Methylpyridin-4-ol|CS-W018581
      18615-86-6
    • null|null
      124-38-9
    • ~%
    • In-stock
      4-Hydroxy-6-methylnicotinic acid|CS-W003138
      67367-33-3

    References

    • Roczniki Chemii, , vol. 31, p. 1147,1151 Chem.Abstr., , p. 10072
  • Route3
    • (3Z)-3-[(Dimethylamino)methylene]-6-methyl-2H-pyran-2,4(3H)-dione|CS-0336743
      181277-21-4
    • ~%
    • In-stock
      4-Hydroxy-6-methylnicotinic acid|CS-W003138
      67367-33-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4998 - 5002

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.79382
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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