Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methoxybenzene-1-sulfonyl chloride

  • CAS No. 67475-56-3

  • Cat. No. CS-W022379
  • Molecule weight224.64
  • Purity≥95%
  • MDL No.MFCD03618459

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxybenzene-1-sulfonyl chloride|CS-W022379

Structure of 67475-56-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 67475-56-3
  • Cat. No. CS-W022379
  • Purity ≥95%
  • MDL No. MFCD03618459
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClFO₃S
  • Molecular Weight 224.64
  • Synonym(s) Benzenesulfonyl chloride, 5-fluoro-2-methoxy-
  • SMILES O=S(C1=CC(F)=CC=C1OC)(Cl)=O

Description

5-Fluoro-2-methoxybenzene-1-sulfonyl chloride features a sulfonyl chloride group flanked by electron-withdrawing fluorine and electron-donating methoxy substituents, enabling selective acylation in synthetic routes. This balance enhances reactivity while maintaining stability under standard conditions, making it ideal for constructing sulfonamide linkages in pharmaceutical intermediates and functional materials.

Application

5-Fluoro-2-methoxybenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its reactivity is enhanced by the electron-withdrawing fluorine and electron-donating methoxy groups, enabling selective functionalization under mild conditions. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for use in medicinal chemistry and process development workflows involving heterocyclic scaffold construction.

Synthesis

  • Route1

    References

    • AVEXA LIMITED; DEADMAN, John, Joseph; JONES, Eric, Dale; LE, Giang, Thanh; RHODES, David, Ian; THIENTHONG, Neeranat; VAN DE GRAFF, Nicholas, Andrew; WINFIELD, Lisa, Jane Patent: WO2010/31 A1, 2010 ; Location in patent: Page/Page column 86 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.7618
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 67475-56-3 sigma67475-56-3 manufacturer67475-56-3 price67475-56-3 structure67475-56-3 SDSbuy 67475-56-367475-56-3 supplier67475-56-3 uses67475-56-3 molecular weightprice of 67475-56-367475-56-3 chemical name formula of 67475-56-3
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label