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Structure of 675-11-6
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4,6-Difluoropyrimidin-2-amine features a highly reactive pyrimidine core with fluorine substituents at the 4 and 6 positions, enabling efficient coupling in nucleophilic substitution reactions. The amino group at position 2 provides a key handle for derivatization, particularly in medicinal chemistry applications. This compound serves as a critical building block for kinase inhibitors and other bioactive heterocycles due to its electron-deficient nature and favorable metabolic stability under standard conditions.
4,6-Difluoropyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via nucleophilic substitution. Its difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the primary amine functionality facilitates coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in constructing heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: