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Structure of 67589-15-5
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1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethanone features a hydroxylated aromatic ring flanked by a trifluoromethyl group and a ketone-bearing side chain. This electron-deficient scaffold integrates readily into synthetic routes requiring polar, moisture-tolerant phenolic ketones.
1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethanone serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aromatic systems. Its ortho-hydroxyl group facilitates chelation and intramolecular cyclization, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity. The ketone functionality allows for diverse transformations including enolization, nucleophilic addition, and reductive amination, making it a practical scaffold for lead optimization and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: