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Structure of 676994-64-2
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5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one features a saturated heterocyclic core that enhances solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, offering a rigid, electron-rich platform for target-directed optimization. The ketone functionality enables direct derivatization and coordination in transition-metal-catalyzed transformations.
5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard functionalization at the 2-position. Its saturated pyridine ring enhances metabolic stability and solubility, while the lactam carbonyl supports hydrogen bonding and structural rigidity. The compound exhibits excellent bench stability and compatibility with common coupling reactions, facilitating efficient access to analogs via amide formation, reductive amination, or electrophilic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: