Methyl 2,5-dichloronicotinate

Name: Methyl 2,5-dichloronicotinate
Brand: ChemScene
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CAS No. 67754-03-4
Cat. No. CS-W005635
Purity≥98%
MDL No.MFCD03844857

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Methyl 2,5-dichloronicotinate|CS-W005635

Structure of 67754-03-4

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Description

Methyl 2,5-dichloronicotinate serves as a key synthetic intermediate in the construction of bioactive heterocycles. The molecule features a pyridine core substituted with chlorine atoms at the 2- and 5-positions and a methyl ester group at the 3-position. This arrangement imparts enhanced electrophilicity and stability under standard bench conditions. The compound integrates readily into transition-metal-catalyzed coupling reactions and facilitates efficient access to functionalized nicotinates for pharmaceutical and agrochemical development.

Application

Methyl 2,5-dichloronicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted nicotinates and heterocyclic scaffolds. Its dual chloro substituents enhance electrophilicity at the ring, facilitating nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The ester functionality allows for selective manipulation under standard conditions, supporting broad functional group tolerance and ease of purification. This compound is bench-stable, readily handled, and widely employed in medicinal chemistry and agrochemical research for constructing bioactive core structures.

General Information

CAS No. 67754-03-4
Cat. No. CS-W005635
Purity ≥98%
MDL No. MFCD03844857
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅Cl₂NO₂
Molecular Weight 206.03
Synonym(s) Methyl 2,5-Dichloropyridine-3-carboxylate
SMILES O=C(OC)C1=C(Cl)N=CC(Cl)=C1

Computational Chemistry Data

TPSA 39.19
LogP 2.175
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Methyl 2,5-dichloronicotinate

CAS No. 67754-03-4

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