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Structure of 69034-09-9
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2-Bromo-5-(trifluoromethyl)pyrimidine is a halogenated pyrimidine scaffold featuring a strongly electron-withdrawing trifluoromethyl group. This combination enables selective cross-coupling reactions, particularly in palladium-catalyzed transformations. The molecule exhibits enhanced stability and reactivity in C–H functionalization and heterocycle synthesis.
2-Bromo-5-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl, heteroaryl, and alkyl substituents at the 2-position. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromine facilitates efficient functionalization under standard Suzuki, Stille, or Negishi conditions. Bench-stable and readily purified, it functions reliably in the synthesis of kinase inhibitors, antiviral agents, and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: