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Structure of 69045-84-7
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2,3-Dichloro-5-trifluoromethylpyridine features a trifluoromethyl group at the 5-position and chlorine substituents at the 2- and 3-positions, creating a highly electron-deficient pyridine core. This combination imparts enhanced reactivity in cross-coupling processes and improves metabolic stability in pharmaceutical intermediates. The molecule exhibits excellent bench stability and compatibility with diverse reaction conditions.
2,3-Dichloro-5-trifluoromethylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-dichloro substitution pattern facilitates selective C–H activation, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H227-H302+H332-H317-H318-H411
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Precautionary Statements : P210-P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P363-P370+P378-P391-P501
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Lot numbers can be found on the outside label of a product: