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Structure of 433-97-6
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2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy.
2-(Trifluoromethyl)benzoic acid serves as a valuable building block in medicinal chemistry and materials science, offering enhanced lipophilicity and metabolic stability due to the electron-withdrawing trifluoromethyl group. It functions effectively in amide coupling, esterification, and Suzuki-type cross-coupling reactions, enabling access to diverse bioactive scaffolds. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, supporting its use in scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: