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CS-W001157 4
Total: USD 88.00

2-Oxopropane-1,3-diyl diacetate

  • CAS No. 6946-10-7

  • Cat. No. CS-0186682
  • Molecule weight174.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Oxopropane-1,3-diyl diacetate|CS-0186682

Structure of 6946-10-7

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General Information

  • CAS No. 6946-10-7
  • Cat. No. CS-0186682
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀O₅
  • Molecular Weight 174.15
  • Synonym(s) Acetic Acid 3-Acetoxy-2-oxopropyl Ester
  • SMILES O=C(COC(C)=O)COC(C)=O

Description

This acetonide derivative features a stable, bench-ready cyclic structure that integrates two acetate esters at the 1,3-positions. Designed for selective protection of diols in complex synthesis, it offers high stability under standard conditions and facilitates straightforward deprotection with mild acid.

Application

2-Oxopropane-1,3-diyl diacetate serves as a stable, bench-ready acetyl donor in organic synthesis, facilitating selective O-acetylation of alcohols and phenols under mild conditions. Its diacetate functionality enables efficient protection of vicinal diol systems, with the ketone moiety providing orthogonal reactivity for downstream transformations. The compound exhibits excellent stability, ease of handling, and compatibility with standard purification methods, making it a practical choice for complex molecule assembly.

Synthesis

  • Route1
    • In-stock
      1,3-Dihydroxyacetone|CS-W019614
      96-26-4
    • null|null
      108-24-7
    • ~83%
    • In-stock
      2-Oxopropane-1,3-diyl diacetate|CS-0186682
      6946-10-7

    References

    • Adam, Jean-Michel; Foricher, Joseph; Hanlon, Steven; Lohri, Bruno; Moine, Gerard; Schmid, Rudolf; Wirz, Beat; Zutter, Ulrich; Stahr, Helmut; Weber, Martin Organic Process Research and Development, 2011 , vol. 15, # 3 p. 515 - 526
  • Route2
    • 2,3,3,3,9,9,10,10-OCtamethyl-4,8-dioxa-3,9-disilaundecan-6-one|CS-0719132
      127382-65-4
    • null|null
      108-24-7
    • ~82%
    • In-stock
      2-Oxopropane-1,3-diyl diacetate|CS-0186682
      6946-10-7

    References

    • Du, Ti-Jian; Wu, Qin-Pei; Liu, Hai-Xia; Chen, Xi; Shu, Yi-Nan; Xi, Xiao-Dong; Zhang, Qing-Shan; Li, Yun-Zheng Tetrahedron, 2011 , vol. 67, # 6 p. 1096 - 1101
  • Route3
    • In-stock
      1,3-Dihydroxyacetone dimer|CS-W013231
      62147-49-3
    • null|null
      108-24-7
    • ~96%
    • In-stock
      2-Oxopropane-1,3-diyl diacetate|CS-0186682
      6946-10-7

    References

    • Suemune; Mizuhara; Akita; Sakai Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 8 p. 3440 - 3444

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.67
  • LogP   -0.3183
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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