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CS-W001157 4
Total: USD 88.00

2-Chlorobenzenesulfonamide

  • CAS No. 6961-82-6

  • Cat. No. CS-W015837
  • Purity≥98%
  • MDL No.MFCD00051974

*For research and further manufacturing use only, not for direct human use.

2-Chlorobenzenesulfonamide|CS-W015837

Structure of 6961-82-6

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General Information

  • CAS No. 6961-82-6
  • Cat. No. CS-W015837
  • Purity ≥98%
  • MDL No. MFCD00051974
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₂S
  • Molecular Weight 191.63
  • Synonym(s) O-Chlorobenzenesulfonamide
  • SMILES O=S(C1=CC=CC=C1Cl)(N)=O

Description

2-Chlorobenzenesulfonamide is a bench-stable sulfonamide featuring a chlorine atom at the ortho position, enhancing its electron-withdrawing character. This substitution pattern improves metabolic stability and facilitates incorporation into bioactive scaffolds for medicinal chemistry applications.

Application

2-Chlorobenzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing heterocycles and bioactive scaffolds. Its ortho-chloro substituent enhances electrophilic reactivity in cross-coupling processes and provides a handle for downstream functionalization. The compound exhibits good bench stability and is compatible with standard purification techniques, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Kureha Kagaku Kogyo K.K. Patent: US6610853 B1, 2003 ;
  • Route2
    • null|null
      1336-21-6
    • In-stock
      2-Chlorobenzenesulfonyl chloride|CS-0072922
      2905-23-9
    • ~66%
    • In-stock
      2-Chlorobenzenesulfonamide|CS-W015837
      6961-82-6

    References

    • Bleisch, Thomas John; Filla, Sandra Ann; Ornstein, Paul Leslie Patent: US2004/63749 A1, 2004 ; US 20040063749 A1
  • Route3

    References

    • Pesticide Science, , vol. 40, # 1 p. 71 - 76

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   0.9874
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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