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CS-W001157 4
Total: USD 88.00

5-Fluoro-2,3-dihydro-1H-inden-1-one

  • CAS No. 700-84-5

  • Cat. No. CS-W008930
  • Molecule weight150.15
  • Purity≥98%
  • MDL No.MFCD00041031

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2,3-dihydro-1H-inden-1-one|CS-W008930

Structure of 700-84-5

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General Information

  • CAS No. 700-84-5
  • Cat. No. CS-W008930
  • Purity ≥98%
  • MDL No. MFCD00041031
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇FO
  • Molecular Weight 150.15
  • Synonym(s) 5-Fluoro-1-indanone
  • SMILES O=C1C2=CC=C(F)C=C2CC1

Description

5-Fluoro-1-indanone was used to prepare precursor for thiosemicarbazones derived from 1-indanones. It was used in the synthesis of 6-fluoro-1,2,3,4-tetrahydroquinoline hydrochloride.

Application

5-Fluoro-2,3-dihydro-1H-inden-1-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated indoline scaffolds via reductive amination or nucleophilic addition. Its bench-stable ketone functionality exhibits broad compatibility with standard coupling and functionalization protocols, facilitating efficient access to bioactive heterocycles.

Synthesis

  • Route1

    References

    • Justus Liebigs Annalen der Chemie, , vol. 736, p. 110 - 125
  • Route2

    References

    • Bulletin de la Societe Chimique de France, , p. 3092 - 3095
  • Route3

    References

    • WO2011/14613 A2, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.9546
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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