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CS-W001157 4
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(S)-3-Amino-3-(m-tolyl)propanoic acid

  • CAS No. 701907-44-0

  • Cat. No. CS-0135740
  • Molecule weight179.22
  • Purity≥97%
  • MDL No.MFCD04113692

*For research and further manufacturing use only, not for direct human use.

(S)-3-Amino-3-(m-tolyl)propanoic acid|CS-0135740

Structure of 701907-44-0

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General Information

  • CAS No. 701907-44-0
  • Cat. No. CS-0135740
  • Purity ≥97%
  • MDL No. MFCD04113692
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO₂
  • Molecular Weight 179.22
  • Synonym(s) (s)-3-Amino-3-(3-methyl-phenyl)-propionic acid
  • SMILES O=C(O)C[C@H](N)C1=CC=CC(C)=C1

Description

(S)-3-Amino-3-(m-tolyl)propanoic acid features a chiral α-amino acid scaffold bearing a meta-tolyl group, delivering enhanced lipophilicity and metabolic stability. This configuration supports efficient incorporation into peptide-based scaffolds and bioactive molecules, particularly in CNS-targeted therapeutics. The molecule exhibits excellent bench stability and solubility under physiological conditions, enabling straightforward handling in synthetic workflows.

Application

(S)-3-Amino-3-(m-tolyl)propanoic acid serves as a valuable chiral building block for medicinal chemistry, enabling the synthesis of bioactive compounds through established peptide coupling and functional group transformation protocols. Its bench-stable nature, combined with orthogonal functionality and high enantiomeric purity, facilitates efficient incorporation into complex scaffolds, including CNS-targeted therapeutics and kinase inhibitors.

Synthesis

  • Route1

    References

    • Advanced Synthesis and Catalysis, , vol. 352, # 9 p. 1409 - 1412

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.46952
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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