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CS-W001157 4
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4-Chloro-2-cyclopropyl-6-methylpyrimidine

  • CAS No. 7043-11-0

  • Cat. No. CS-0071281
  • Purity≥96%
  • MDL No.MFCD12032988

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-cyclopropyl-6-methylpyrimidine|CS-0071281

Structure of 7043-11-0

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General Information

  • CAS No. 7043-11-0
  • Cat. No. CS-0071281
  • Purity ≥96%
  • MDL No. MFCD12032988
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClN₂
  • Molecular Weight 168.62
  • Synonym(s) 4-chloro-2-cyclopropyl-6-methyl-pyrimidine
  • SMILES ClC1=CC(C)=NC(C2CC2)=N1

Description

4-Chloro-2-cyclopropyl-6-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and favorable lipophilicity. The cyclopropyl group imparts conformational rigidity, while the chloro and methyl substituents enable strategic electronic tuning for target engagement. This compound integrates efficiently into kinase inhibitor frameworks and other bioactive molecules under standard conditions.

Application

4-Chloro-2-cyclopropyl-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates palladium-catalyzed cross-coupling reactions, while the cyclopropyl and methyl substituents provide steric and electronic tuning for target-specific optimization. The compound exhibits good bench stability and compatibility with standard purification methods, making it suitable for high-throughput synthesis and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.31582
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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