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Structure of 704884-74-2
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5-Fluoro-2-hydroxy-3-methylbenzaldehyde features a trifunctional aromatic core with fluorine, hydroxyl, and methyl substituents positioned for orthogonal reactivity. The electron-deficient aryl ring pairs with the aldehyde handle to enable efficient coupling in Suzuki-Miyaura and Ullmann-type transformations. This bench-stable scaffold integrates readily into complex heterocyclic systems and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive scaffolds.
5-Fluoro-2-hydroxy-3-methylbenzaldehyde serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxy and meta-fluoro substituents enable directed metalation and selective functionalization, while the aldehyde group supports efficient imine formation and reductive amination. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H315-H317-H318-H335
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Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: