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Structure of 716362-12-8
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4-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid is a fluorinated heterocyclic building block featuring a carboxylic acid group at the 3-position and a trifluoromethyl substituent at the 4-position. This combination imparts enhanced metabolic stability, improved lipophilicity, and favorable electronic properties for drug discovery applications. The molecule integrates readily into bioactive scaffolds, particularly in kinase inhibitors and CNS-targeted therapeutics.
4-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct derivatization or conjugation in peptide and small-molecule synthesis. The compound exhibits excellent bench stability and compatibility with common reaction conditions, making it a practical choice for iterative lead optimization and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: