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Structure of 72045-93-3
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This trifluoromethyl-substituted aniline integrates a chlorinated aryl ring with a pyridine-oxide linkage, delivering enhanced electron-withdrawing character and improved metabolic stability. The ortho-chloro group enables selective coupling reactions, while the para-trifluoromethylpyridin-2-yl ether moiety imparts high lipophilicity and resistance to oxidative degradation, making it valuable for medicinal chemistry applications requiring robust scaffold integrity under physiological conditions.
3-Chloro-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)aniline serves as a versatile building block for pharmaceutical intermediates, enabling direct coupling in Suzuki-Miyaura and Buchwald-Hartwig reactions. The chloro group facilitates palladium-catalyzed cross-coupling, while the pyridine-N and aniline functionalities offer orthogonal reactivity. Bench-stable and compatible with standard purification methods, it supports efficient synthesis of complex heterocyclic scaffolds relevant to kinase inhibitors and targeted therapeutics.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P363-P405-P501
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Lot numbers can be found on the outside label of a product: