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CS-W001157 4
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2-(Prop-2-yn-1-yl)isoindoline-1,3-dione

  • CAS No. 7223-50-9

  • Cat. No. CS-0059174
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

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*For research and further manufacturing use only, not for direct human use.

2-(Prop-2-yn-1-yl)isoindoline-1,3-dione|CS-0059174

Structure of 7223-50-9

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Description

This isoindoline-1,3-dione derivative features a propargyl group at the 2-position, enabling efficient copper-catalyzed azide-alkyne cycloaddition. The electron-deficient dione core facilitates conjugate addition reactions, while the alkyne handle offers orthogonal reactivity for bioconjugation and materials functionalization under mild conditions.

Application

2-(Prop-2-yn-1-yl)isoindoline-1,3-dione serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized isoindolinone scaffolds. The terminal alkyne group facilitates CuAAC and other transition-metal-catalyzed coupling reactions, while the phthalimide moiety provides excellent stability and orthogonal reactivity. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for modular synthesis workflows in medicinal chemistry and materials science.

General Information

  • CAS No. 7223-50-9
  • Cat. No. CS-0059174
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇NO₂
  • Molecular Weight 185.18
  • Synonym(s) N-Propargylphthalimide
  • SMILES O=C1N(CC#C)C(C2=C1C=CC=C2)=O

Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.9158
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

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