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CS-W001157 4
Total: USD 88.00

5-Quinolinecarboxylic acid

  • CAS No. 7250-53-5

  • Cat. No. CS-W004029
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD00047608

*For research and further manufacturing use only, not for direct human use.

5-Quinolinecarboxylic acid|CS-W004029

Structure of 7250-53-5

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General Information

  • CAS No. 7250-53-5
  • Cat. No. CS-W004029
  • Purity ≥95%
  • MDL No. MFCD00047608
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO₂
  • Molecular Weight None
  • Synonym(s) Quinoline-5-carboxylic acid
  • SMILES O=C(O)C1=CC=CC2=C1C=CC=N2

Description

5-Quinolinecarboxylic acid delivers a rigid, electron-deficient heteroaromatic scaffold ideal for conjugation and metal coordination. This bench-stable carboxylic acid integrates readily into synthetic sequences, serving as a structural anchor in ligand design and pharmaceutical intermediates.

Application

5-Quinolinecarboxylic acid serves as a versatile building block in medicinal chemistry and catalysis, enabling direct functionalization at the C5 position of the quinoline core. Its carboxylic acid group facilitates amide coupling, esterification, and metal coordination, supporting synthesis of kinase inhibitors, ligands, and pharmaceutical intermediates. The compound exhibits good bench stability and compatibility with standard purification methods, making it suitable for scalable transformations and heterocyclic scaffold elaboration.

Synthesis

  • Route1

    References

    • WO2013/128465 A1, ; Page/Page column 203 ;
  • Route2

    References

    • Tulyaganov, T. S.; Ibragimov, A. A.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1982 , vol. 18, p. 601 - 603 Khimiya Prirodnykh Soedinenii, 1982 , vol. 18, # 5 p. 635 - 638
  • Route3

    References

    • Chemische Berichte, , vol. 43, p. 3031

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.933
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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