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CS-W001157 4
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1-(4-Amino-2-chlorophenyl)ethanone

  • CAS No. 72531-23-8

  • Cat. No. CS-0038878
  • Molecule weight169.61
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Amino-2-chlorophenyl)ethanone|CS-0038878

Structure of 72531-23-8

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General Information

  • CAS No. 72531-23-8
  • Cat. No. CS-0038878
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClNO
  • Molecular Weight 169.61
  • Synonym(s) 1-(4-amino-2-chloro-phenyl)-ethanone
  • SMILES CC(=O)C1=C(C=C(C=C1)N)Cl

Description

1-(4-Amino-2-chlorophenyl)ethanone features a chlorinated aromatic core paired with a pendant acetamido group, enabling integration into bioactive scaffolds. The para-amino functionality supports derivatization and conjugation, while the electron-withdrawing chlorine enhances reactivity in electrophilic substitution processes. This compound exhibits robust stability under standard bench conditions and facilitates efficient incorporation into pharmaceutical intermediates and functional materials.

Application

1-(4-Amino-2-chlorophenyl)ethanone serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its amine and chloro functionalities enable diverse coupling reactions and electrophilic substitutions, while the acetophenone moiety supports facile functionalization via enolization or reduction. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring orthogonal reactivity.

Synthesis

  • Route1

    References

    • US2009/88425 A1, ; Page/Page column 39 ; US 20090088425 A1
  • Route2
    • In-stock
      1-(2-Chloro-4-nitrophenyl)ethanone|CS-W021200
      67818-41-1
    • null|null
      96042-30-7
    • ~%
    • In-stock
      1-(4-Amino-2-chlorophenyl)ethanone|CS-0038878
      72531-23-8

    References

    • US2010/249139 A1, ; US 20100249139 A1
  • Route3
    • null|null
      103273-72-9
    • ~%
    • In-stock
      1-(4-Amino-2-chlorophenyl)ethanone|CS-0038878
      72531-23-8

    References

    • Journal of the Indian Chemical Society, , vol. 36, p. 99,101

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   2.1248
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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