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CS-W001157 4
Total: USD 88.00

2-Chloro-3-nitro-5-(trifluoromethyl)pyridine

  • CAS No. 72587-15-6

  • Cat. No. CS-W005659
  • Purity≥96%
  • MDL No.MFCD06255171
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-nitro-5-(trifluoromethyl)pyridine|CS-W005659

Structure of 72587-15-6

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Description

2-Chloro-3-nitro-5-(trifluoromethyl)pyridine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the chloro and nitro substituents enable selective cross-coupling and functionalization under mild conditions. This pyridine derivative serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates.

Application

2-Chloro-3-nitro-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling. Its trifluoromethyl and nitro groups enhance electron-withdrawing character, facilitating nucleophilic substitution at the C2 position. The molecule exhibits good bench stability and compatibility with common protecting group strategies, supporting efficient synthesis of heterocyclic scaffolds relevant to agrochemical and pharmaceutical development.

General Information

  • CAS No. 72587-15-6
  • Cat. No. CS-W005659
  • Purity ≥96%
  • MDL No. MFCD06255171
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClF₃N₂O₂
  • Molecular Weight 226.54
  • Synonym(s) 2-chloro-5-(trifluoroMethyl)-3-nitropyridine
  • SMILES FC(C1=CN=C(Cl)C([N+]([O-])=O)=C1)(F)F

Computational Chemistry Data

  • TPSA   56.03
  • LogP   2.662
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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