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CS-W001157 4
Total: USD 88.00

5,6-dimethoxy-1H-benzimidazole

  • CAS No. 72721-02-9

  • Cat. No. CS-0007000
  • Purity≥97%
  • MDL No.MFCD00612461

*For research and further manufacturing use only, not for direct human use.

5,6-dimethoxy-1H-benzimidazole|CS-0007000

Structure of 72721-02-9

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General Information

  • CAS No. 72721-02-9
  • Cat. No. CS-0007000
  • Purity ≥97%
  • MDL No. MFCD00612461
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀N₂O₂
  • Molecular Weight 178.19
  • Synonym(s) 5,6-Dimethoxybenzimidazole
  • SMILES COC1=C(OC)C=C2C(NC=N2)=C1

Description

5,6-Dimethoxy-1H-benzimidazole features two methoxy groups at the 5- and 6-positions of the benzimidazole core, enhancing solubility and electronic modulation. This electron-rich heterocycle serves as a stable scaffold in synthetic organic chemistry, enabling efficient coupling reactions and functionalization under mild conditions.

Application

5,6-Dimethoxy-1H-benzimidazole serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its ortho-dimethoxy substitution enhances solubility and modulates electronic properties, enabling reliable coupling reactions and transition-metal-catalyzed transformations. The benzimidazole core exhibits robust bench stability and compatibility with diverse functional groups, facilitating efficient synthesis of complex scaffolds for API development and functional molecular design.

Synthesis

  • Route1
    • null|null
      64-18-6
    • In-stock
      4,5-Dimethoxybenzene-1,2-diamine|CS-0006999
      27841-33-4
    • ~%
    • In-stock
      5,6-dimethoxy-1H-benzimidazole|CS-0007000
      72721-02-9

    References

    • US2007/203210 A1, ; Page/Page column 41 ;
  • Route2
    • null|null
      64-18-6
    • 4,5-Dimethoxybenzene-1,2-diamine hydrochloride|CS-0676901
      88580-71-6
    • ~%
    • In-stock
      5,6-dimethoxy-1H-benzimidazole|CS-0007000
      72721-02-9

    References

    • Journal of Organic Chemistry, , vol. 24, p. 1451,1452, 1453

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.14
  • LogP   1.5801
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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