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Structure of 78581-99-4
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5,6-Difluorobenzimidazole features a fluorinated benzimidazole core with enhanced electron deficiency, enabling robust coupling in transition metal-catalyzed reactions. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds and bioactive molecules, offering improved metabolic stability and membrane permeability.
5,6-Difluorobenzimidazole serves as a valuable heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and modulated basicity due to the electron-withdrawing fluorine substituents. It functions as a key scaffold in kinase inhibitors and CNS-targeted therapeutics, enabling efficient coupling reactions via its imidazole nitrogen atoms. The compound exhibits good bench stability, facilitates straightforward purification, and demonstrates broad compatibility with standard cross-coupling and derivatization protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: