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CS-W001157 4
Total: USD 88.00

2-Chloro-6-(trifluoromethyl)pyridin-3-ol

  • CAS No. 731002-60-1

  • Cat. No. CS-0060446
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-(trifluoromethyl)pyridin-3-ol|CS-0060446

Structure of 731002-60-1

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General Information

  • CAS No. 731002-60-1
  • Cat. No. CS-0060446
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₃NO
  • Molecular Weight 197.54
  • Synonym(s) None
  • SMILES C1=CC(=NC(=C1O)Cl)C(F)(F)F

Description

2-Chloro-6-(trifluoromethyl)pyridin-3-ol features a trifluoromethyl group at the pyridine ring's 6-position, enhancing electron deficiency and metabolic stability. The ortho-chloro and phenolic hydroxyl groups enable direct coupling in cross-coupling reactions or serve as anchors for further functionalization. This bench-stable scaffold integrates efficiently into bioactive molecules and advanced materials.

Application

2-Chloro-6-(trifluoromethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring due to its orthogonal reactivity profile. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the phenolic hydroxyl supports derivatization or metal complexation. Its stability under standard bench conditions and compatibility with diverse reaction environments make it ideal for constructing bioactive heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.4594
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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