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CS-W001157 4
Total: USD 88.00

3-Phenyl-3-(trifluoromethyl)-3H-diazirine

  • CAS No. 73899-14-6

  • Cat. No. CS-0008636
  • Purity≥95%
  • MDL No.MFCD22041649
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Phenyl-3-(trifluoromethyl)-3H-diazirine|CS-0008636

Structure of 73899-14-6

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Description

3-Phenyl-3-(trifluoromethyl)-3H-diazirine is a bench-stable, moisture-tolerant photoaffinity label featuring a highly reactive diazirine ring. This trifluoromethyl-substituted aryl diazirine integrates readily into bioconjugation workflows, enabling site-specific protein crosslinking upon UV irradiation. The electron-withdrawing trifluoromethyl group enhances photolysis efficiency while stabilizing the carbene intermediate formed during activation.

Application

3-Phenyl-3-(trifluoromethyl)-3H-diazirine serves as a stable, bench-compatible photoaffinity labeling agent, enabling site-specific covalent capture of interacting biomolecules upon UV irradiation. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the diazirine ring undergoes efficient photolysis to generate reactive carbene intermediates. This compound facilitates targeted protein-ligand interaction studies and is compatible with diverse biological matrices and downstream analytical workflows.

General Information

  • CAS No. 73899-14-6
  • Cat. No. CS-0008636
  • Purity ≥95%
  • MDL No. MFCD22041649
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃N₂
  • Molecular Weight 186.13
  • Synonym(s) 3-phenyl-3-(trifluoromethyl)diazirine
  • SMILES FC(C1(C2=CC=CC=C2)N=N1)(F)F

Computational Chemistry Data

  • TPSA   24.72
  • LogP   2.8675
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅱ
Hazard Statements : H226-H314-H318
Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501

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