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CS-W001157 4
Total: USD 88.00

(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid

  • CAS No. 74131-06-9

  • Cat. No. CS-0524047
  • Purity≥98%
  • MDL No.MFCD01631045

*For research and further manufacturing use only, not for direct human use.

(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid|CS-0524047

Structure of 74131-06-9

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General Information

  • CAS No. 74131-06-9
  • Cat. No. CS-0524047
  • Purity ≥98%
  • MDL No. MFCD01631045
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄N₂O₇
  • Molecular Weight 298.25
  • Synonym(s) (E)-5-(2-CARBOXYVINYL)-2'-DEOXYURIDINE
  • SMILES OC[C@@H]1[C@H](C[C@H](N2C(NC(C(/C=C/C(O)=O)=C2)=O)=O)O1)O

Synthesis

  • Route1
    • Methyl (E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylate|CS-0459211
      86163-17-9
    • ~92%
    • (E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid|CS-0524047
      74131-06-9

    References

    • Rong; Soloway Nucleosides and Nucleotides, 1994 , vol. 13, # 9 p. 2021 - 2034
  • Route2

    References

    • EP2130835 A1, ; Page/Page column 40 ;
  • Route3

    References

    • Garg, Neil K.; Woodroofe, Carolyn C.; Lacenere, Christopher J.; Quake, Stephen R.; Stoltz, Brian M. Chemical Communications, 2005 , # 36 p. 4551 - 4553

Safety Information

Download SDS
GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   141.85
  • LogP   -1.7249
  • H_Acceptors   7
  • H_Donors   4
  • Rotatable_Bonds   4

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