Lot numbers can be found on the outside label of a product:
2,2,2-Trimethylacetamide
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CAS No. 754-10-9
- Cat. No. CS-W021470
- Purity≥98%
- MDL No.MFCD00008011
*For research and further manufacturing use only, not for direct human use.
Structure of 754-10-9
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General Information
- CAS No. 754-10-9
- Cat. No. CS-W021470
- Purity ≥98%
- MDL No. MFCD00008011
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₁₁NO
- Molecular Weight 101.15
- Synonym(s) Trimethylacetamide, (Pivalamide)
- SMILES O=C(N)C(C)(C)C
Description
2,2,2-Trimethylacetamide is a sterically hindered amide featuring a bulky trimethylacetyl group. This structure imparts exceptional stability and low nucleophilicity, making it ideal for use in sensitive synthetic transformations. The molecule’s high boiling point and low water solubility enable efficient separation and purification workflows. It serves as a robust solvent and reaction medium under standard bench conditions.
Application
2,2,2-Trimethylacetamide serves as a stable, bench-friendly amide solvent and acylating agent, enabling efficient N-acylation reactions with excellent functional group tolerance. Its sterically hindered structure enhances hydrolytic stability and simplifies purification, making it well-suited for peptide coupling and heterocycle synthesis in medicinal chemistry workflows.
Synthesis
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Route1
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In-stock
630-18-2 - ~96%
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In-stock
754-10-9
References
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Goto, Akihiro; Endo, Kohei; Saito, Susumu Angewandte Chemie - International Edition, 2008 , vol. 47, # 19 p. 3607 - 3609
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Route2
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In-stock
75-98-9 - ~91%
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In-stock
754-10-9
References
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Mizuhara, Tsukasa; Hioki, Kazuhito; Yamada, Megumi; Sasaki, Hideaki; Morisaki, Daiki; Kunishima, Munetaka Chemistry Letters, 2008 , vol. 37, # 12 p. 1191 - 1192
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Route3
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In-stock
39785-37-0 -
3282-30-2 - ~85%
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181422-51-5
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In-stock
754-10-9
References
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Research Development Foundation Patent: US5674876 A1, 1997 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.09
- LogP 0.5178
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
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