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CS-W001157 4
Total: USD 88.00

1,2,4-Thiadiazol-5-amine

  • CAS No. 7552-07-0

  • Cat. No. CS-0037734
  • Purity≥97%
  • MDL No.MFCD01102171

*For research and further manufacturing use only, not for direct human use.

1,2,4-Thiadiazol-5-amine|CS-0037734

Structure of 7552-07-0

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General Information

  • CAS No. 7552-07-0
  • Cat. No. CS-0037734
  • Purity ≥97%
  • MDL No. MFCD01102171
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₃N₃S
  • Molecular Weight 101.13
  • Synonym(s) 5-Amino-1,2,4-thiadiazole
  • SMILES NC1=NC=NS1

Description

1,2,4-Thiadiazol-5-amine features a heterocyclic core with nitrogen and sulfur atoms that imparts enhanced stability and hydrogen-bonding capacity. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in medicinal chemistry. The amine group enables direct derivatization, while the electron-deficient ring facilitates interactions with biological targets.

Application

1,2,4-Thiadiazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its nitrogen-rich core enables robust metal coordination and enhances molecular polarity, facilitating purification and crystallization. The amine functionality supports diverse derivatization via amidation, alkylation, and coupling reactions, making it valuable for constructing bioactive scaffolds and functional polymers. Bench-stable and readily handled, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      943653-32-5
    • ~46%
    • In-stock
      1,2,4-Thiadiazol-5-amine|CS-0037734
      7552-07-0

    References

    • US2009/124655 A1, ; Page/Page column 14 ; US 20090124655 A1
  • Route2
    • null|null
      333-20-0
    • In-stock
      Formimidamide hydrochloride|CS-W007673
      6313-33-3
    • ~%
    • In-stock
      1,2,4-Thiadiazol-5-amine|CS-0037734
      7552-07-0

    References

    • Chemische Berichte, , vol. 87, p. 68,74 Chemische Berichte, , vol. 89, p. 1534,1540
  • Route3
    • null|null
      115948-81-7
    • null|null
      333-20-0
    • ~%
    • In-stock
      1,2,4-Thiadiazol-5-amine|CS-0037734
      7552-07-0

    References

    • Chemische Berichte, , vol. 87, p. 68,74 Chemische Berichte, , vol. 89, p. 1534,1540

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.1203
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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