2,4-Dichloro-1-ethynylbenzene

Name: 2,4-Dichloro-1-ethynylbenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 75717-77-0
Cat. No. CS-0038398
Purity≥98%
MDL No.MFCD11655752

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-1-ethynylbenzene|CS-0038398

Structure of 75717-77-0

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Description

2,4-Dichloro-1-ethynylbenzene features a reactive alkyne handle flanked by two electron-withdrawing chlorine atoms, enabling efficient coupling in transition-metal-catalyzed transformations. This bench-stable arylacetylene integrates readily into conjugated frameworks and serves as a robust building block for functionalized arenes under standard conditions.

Application

2,4-Dichloro-1-ethynylbenzene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of conjugated biaryl and heteroaryl architectures. The ethynyl group facilitates Sonogashira coupling with aryl halides, while the dichloro substitution pattern supports sequential functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis of complex scaffolds in medicinal chemistry and materials science.

General Information

CAS No. 75717-77-0
Cat. No. CS-0038398
Purity ≥98%
MDL No. MFCD11655752
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄Cl₂
Molecular Weight 171.02
Synonym(s) 2,4-dichloro ethynylbenzene
SMILES C#CC1=CC=C(C=C1Cl)Cl

Computational Chemistry Data

TPSA 0
LogP 2.9747
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

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2,4-Dichloro-1-ethynylbenzene

CAS No. 75717-77-0

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