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Structure of 75893-82-2
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6-Fluoro-3,4-dihydroquinolin-2(1H)-one features a fluorinated quinolinone core with enhanced metabolic stability and improved membrane permeability. This scaffold integrates a polar carbonyl group with a strategically positioned fluorine atom, enabling strong hydrogen bonding and favorable electronic interactions in biological targets. The compound serves as a key intermediate in medicinal chemistry for developing kinase inhibitors and CNS-active agents.
6-Fluoro-3,4-dihydroquinolin-2(1H)-one serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its fluorinated aromatic core enables enhanced metabolic stability and modulated electronic properties, while the enolizable carbonyl facilitates nucleophilic additions and condensation reactions. Bench-stable and compatible with standard coupling protocols, it functions effectively in the synthesis of bioactive scaffolds and API intermediates requiring controlled polarity and hydrogen-bonding capacity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: