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CS-W001157 4
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(2-Fluoro-3-methylphenyl)boronic acid

  • CAS No. 762287-58-1

  • Cat. No. CS-0113029
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD06409950

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-3-methylphenyl)boronic acid|CS-0113029

Structure of 762287-58-1

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General Information

  • CAS No. 762287-58-1
  • Cat. No. CS-0113029
  • Purity ≥97%
  • MDL No. MFCD06409950
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₂
  • Molecular Weight None
  • Synonym(s) boronic acid, B-(2-fluoro-3-methylphenyl)-
  • SMILES FC1=C(C=CC=C1B(O)O)C

Description

This boronic acid features a fluorinated aryl moiety paired with a methyl substituent, enabling selective cross-coupling reactivity in palladium-catalyzed transformations. The ortho-fluoro group enhances stability and modulates electronic properties, while the methyl group introduces steric control. Bench-stable and compatible with standard coupling conditions, it facilitates efficient access to substituted biaryl architectures in medicinal chemistry and materials synthesis.

Application

(2-Fluoro-3-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro and meta-methyl substituents provide predictable regiochemical control and enhanced stability compared to non-fluorinated analogs. The boronic acid functions reliably in diverse synthetic workflows, offering excellent bench stability, straightforward purification, and broad functional group tolerance—making it a practical choice for constructing biaryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.18608
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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