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Structure of 766-05-2
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Cyclohexanecarbonitrile was used as model substrate in rhodium-catalyzed direct ortho-arylation reactions of phenylazoles using arylboron reagents. It was used as probe in the synthesis of an asymmetric, C-magnesiated nitrile.
Cyclohexanecarbonitrile serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized alkyl chains. Its nitrile group exhibits robust stability under standard bench conditions and undergoes well-documented transformations including hydrolysis to carboxylic acids, reduction to primary amines, and participation in nucleophilic addition reactions. The molecule's rigid cyclohexane framework provides structural definition, enhancing its utility in medicinal chemistry lead optimization and process-scale synthesis.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3276
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H301
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Precautionary Statements : P210-P264-P270-P280-P330-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: