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CS-W001157 4
Total: USD 88.00

(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity

  • CAS No. 7689-03-4

  • Cat. No. CS-0167146
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD00081076

*For research and further manufacturing use only, not for direct human use.

(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146

Structure of 7689-03-4

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General Information

  • CAS No. 7689-03-4
  • Cat. No. CS-0167146
  • Purity ≥97%
  • MDL No. MFCD00081076
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₆N₂O₄
  • Molecular Weight None
  • Synonym(s) (+)-Camptothecin;(S)-(+)-Camptothecin;Camptothecin;CPT
  • SMILES CC[C@@]1(C2=C(COC1=O)C(N3C(C4=NC5=CC=CC=C5C=C4C3)=C2)=O)O

Synthesis

  • Route1
    • null|null
      146596-04-5
    • ~57%
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4

    References

    • Comins; Baevsky; Hong Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972
  • Route2
    • null|null
      841276-70-8
    • ~68%
    • (R)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione  Irinotecan Impurity|CS-0164099
      110351-92-3
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4

    References

    • Zhou, Hai-Bin; Liu, Guan-Sai; Yao, Zhu-Jun Organic Letters, 2007 , vol. 9, # 10 p. 2003 - 2005
  • Route3
    • null|null
      390824-47-2
    • ~64%
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4

    References

    • Zhao, Lei; Xiong, Fang-Jun; Chen, Wen-Xue; Chen, Fen-Er Synthesis, 2011 , # 24 art. no. F87011SS, p. 4045 - 4049

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 1544
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H340
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   81.42
  • LogP   2.0796
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   1

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