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CS-W001157 4
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5-ethyl-2-pyridinecarboxylic acid

  • CAS No. 770-08-1

  • Cat. No. CS-0000172
  • Molecule weight151.16
  • Purity≥97%
  • MDL No.MFCD00995160

*For research and further manufacturing use only, not for direct human use.

5-ethyl-2-pyridinecarboxylic acid|CS-0000172

Structure of 770-08-1

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General Information

  • CAS No. 770-08-1
  • Cat. No. CS-0000172
  • Purity ≥97%
  • MDL No. MFCD00995160
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) 5-Ethylpicolinic acid
  • SMILES O=C(O)C(C=C1)=NC=C1CC

Description

5-Ethyl-2-pyridinecarboxylic acid features a pyridine ring bearing an electron-deficient nitrogen and a carboxylic acid group at the 2-position, with an ethyl substituent at the 5-position. This configuration enhances solubility in organic solvents while maintaining thermal stability. The molecule integrates readily into heterocyclic scaffolds for medicinal chemistry applications.

Application

5-Ethyl-2-pyridinecarboxylic acid serves as a versatile building block for pyridine-based heterocycles, enabling efficient functionalization in medicinal chemistry and agrochemical synthesis. The carboxylic acid group facilitates amide coupling, esterification, and derivatization under standard conditions, while the ethyl substituent enhances lipophilicity and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring orthogonal reactivity.

Synthesis

  • Route1
    • null|null
      104-90-5
    • ~4%
    • In-stock
      6-Methylnicotinic acid|CS-W008333
      3222-47-7
    • In-stock
      5-ethyl-2-pyridinecarboxylic acid|CS-0000172
      770-08-1
    • 2,5-Pyridinedicarboxylic acid Nicotinic Acid  Impurity|CS-0229402
      100-26-5

    References

    • Pharmaceutical Chemistry Journal, , vol. 26, # 11/12 p. 894 - 896 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 11-12 p. 81 - 83
  • Route2
    • null|null
      5408-74-2
    • ~%
    • In-stock
      5-ethyl-2-pyridinecarboxylic acid|CS-0000172
      770-08-1

    References

    • US2749350 , ;
  • Route3
    • null|null
      104-90-5
    • null|null
      108-99-6
    • ~%
    • In-stock
      5-ethyl-2-pyridinecarboxylic acid|CS-0000172
      770-08-1

    References

    • Justus Liebigs Annalen der Chemie, , vol. 613, p. 153,155, 162

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3422
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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