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CS-W001157 4
Total: USD 88.00

3-Chloro-4-iodopyridine

  • CAS No. 77332-79-7

  • Cat. No. CS-W002592
  • Purity≥98%
  • MDL No.MFCD00272199

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-iodopyridine|CS-W002592

Structure of 77332-79-7

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General Information

  • CAS No. 77332-79-7
  • Cat. No. CS-W002592
  • Purity ≥98%
  • MDL No. MFCD00272199
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClIN
  • Molecular Weight None
  • Synonym(s) 3-Chlor-4-iodpyridin; 3-Chloro-4-iodopyridine
  • SMILES ClC1=CN=CC=C1I

Description

3-Chloro-4-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization, with the iodine group facilitating efficient palladium-catalyzed coupling and the chlorine offering orthogonal reactivity. This dual-halogenation pattern supports modular synthesis in medicinal chemistry and materials science.

Application

3-Chloro-4-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of substituted pyridine scaffolds. The orthogonal reactivity of the chloro and iodo groups facilitates sequential functionalization via Pd-catalyzed coupling reactions. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Jensen, Thomas; Pedersen, Henrik; Bang-Andersen, Benny; Madsen, Robert; Jorgensen, Morten Angewandte Chemie - International Edition, 2008 , vol. 47, # 5 p. 888 - 890
  • Route2

    References

    • Gribble, Gordon W.,; Saulnier, Mark G. Tetrahedron Letters, 1980 , vol. 21, p. 4137 - 4140

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3396
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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