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Structure of 77532-78-6
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2-Bromo-6-methylbenzonitrile features a strategically positioned bromine atom and nitrile group on a methyl-substituted benzene ring, enabling direct functionalization in cross-coupling reactions. The electron-withdrawing nitrile enhances reactivity at the bromine site, while the methyl group provides steric stabilization. This combination delivers a bench-stable, moisture-tolerant building block for synthesizing complex heterocycles and pharmaceutical intermediates under standard conditions.
2-Bromo-6-methylbenzonitrile serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable aryl bromide functionality and electron-withdrawing nitrile group. The methyl substituent provides steric and electronic modulation, enhancing regioselectivity in downstream transformations. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for constructing complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: