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Structure of 779345-37-8
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5-Fluoro-2-nitropyridine features a fluorine atom at the 5-position and a nitro group at the 2-position on a pyridine core, creating a highly electron-deficient heteroaromatic system. This combination enables efficient coupling reactions in cross-coupling and C–H functionalization processes, particularly under palladium catalysis. The molecule exhibits enhanced reactivity due to synergistic electronic effects from both substituents.
5-Fluoro-2-nitropyridine serves as a versatile building block in synthetic organic chemistry, enabling regioselective nucleophilic substitution reactions due to the ortho-fluorine relative to the nitro group. Its compatibility with palladium-catalyzed cross-coupling processes and utility in constructing nitrogen-containing heterocycles make it valuable for medicinal chemistry and agrochemical research. The compound exhibits good bench stability and facilitates straightforward purification, supporting scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: