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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-nitropyridine

  • CAS No. 779345-37-8

  • Cat. No. CS-D0783
  • Purity≥98%
  • MDL No.MFCD03092917
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-nitropyridine|CS-D0783

Structure of 779345-37-8

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Description

5-Fluoro-2-nitropyridine features a fluorine atom at the 5-position and a nitro group at the 2-position on a pyridine core, creating a highly electron-deficient heteroaromatic system. This combination enables efficient coupling reactions in cross-coupling and C–H functionalization processes, particularly under palladium catalysis. The molecule exhibits enhanced reactivity due to synergistic electronic effects from both substituents.

Application

5-Fluoro-2-nitropyridine serves as a versatile building block in synthetic organic chemistry, enabling regioselective nucleophilic substitution reactions due to the ortho-fluorine relative to the nitro group. Its compatibility with palladium-catalyzed cross-coupling processes and utility in constructing nitrogen-containing heterocycles make it valuable for medicinal chemistry and agrochemical research. The compound exhibits good bench stability and facilitates straightforward purification, supporting scalable synthesis workflows.

General Information

  • CAS No. 779345-37-8
  • Cat. No. CS-D0783
  • Purity ≥98%
  • MDL No. MFCD03092917
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FN₂O₂
  • Molecular Weight 142.09
  • Synonym(s) 5-Fluoro-2-nitro-pyridine
  • SMILES O=[N+](C1=NC=C(F)C=C1)[O-]

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.1289
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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