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CS-W001157 4
Total: USD 88.00

1-(2,3,4-Trifluorophenyl)ethanamine

  • CAS No. 780027-85-2

  • Cat. No. CS-0161975
  • Purity≥97%
  • MDL No.MFCD17254431

*For research and further manufacturing use only, not for direct human use.

1-(2,3,4-Trifluorophenyl)ethanamine|CS-0161975

Structure of 780027-85-2

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General Information

  • CAS No. 780027-85-2
  • Cat. No. CS-0161975
  • Purity ≥97%
  • MDL No. MFCD17254431
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃N
  • Molecular Weight 175.15
  • Synonym(s) None
  • SMILES CC(N)C1=CC=C(F)C(F)=C1F

Description

1-(2,3,4-Trifluorophenyl)ethanamine features a trifluorinated aromatic ring that enhances electron-withdrawing character and metabolic stability. This amine integrates readily into bioactive scaffolds, offering improved lipophilicity and membrane permeability for medicinal chemistry applications.

Application

1-(2,3,4-Trifluorophenyl)ethanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amine functionalization. Its trifluorophenyl moiety enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates conjugation in amide couplings, reductive aminations, and electrophilic substitutions. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.1236
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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