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CS-W001157 4
Total: USD 88.00

2,5-Dichloro-4-(trifluoromethyl)pyrimidine

  • CAS No. 785777-98-2

  • Cat. No. CS-W021518
  • Purity≥98%
  • MDL No.MFCD13176599
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloro-4-(trifluoromethyl)pyrimidine|CS-W021518

Structure of 785777-98-2

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Description

2,5-Dichloro-4-(trifluoromethyl)pyrimidine features a highly electron-deficient pyrimidine core flanked by two chlorine atoms and a trifluoromethyl group, enabling robust coupling reactions under standard conditions. This bench-stable heterocycle integrates efficiently into pharmaceutical scaffolds and serves as a key building block for agrochemicals and advanced materials.

Application

2,5-Dichloro-4-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its electrophilic C2 and C5 positions facilitate nucleophilic substitution under mild conditions, offering high functional group tolerance and compatibility with diverse coupling partners. Bench-stable and readily purified, it functions efficiently in late-stage diversification strategies for drug discovery and API development.

General Information

  • CAS No. 785777-98-2
  • Cat. No. CS-W021518
  • Purity ≥98%
  • MDL No. MFCD13176599
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅HCl₂F₃N₂
  • Molecular Weight 216.98
  • Synonym(s) None
  • SMILES FC(C1=NC(Cl)=NC=C1Cl)(F)F

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.8022
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 3082
Class : 9
Packing Group :
Hazard Statements : H302-H318-H410
Precautionary Statements : P264-P270-P273-P280-P305+P351+P338-P330-P391-P501

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