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CS-W001157 4
Total: USD 88.00

2,5-Dichloro-4-(trifluoromethyl)pyrimidine

  • CAS No. 785777-98-2

  • Cat. No. CS-W021518
  • Purity≥98%
  • MDL No.MFCD13176599

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloro-4-(trifluoromethyl)pyrimidine|CS-W021518

Structure of 785777-98-2

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General Information

  • CAS No. 785777-98-2
  • Cat. No. CS-W021518
  • Purity ≥98%
  • MDL No. MFCD13176599
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅HCl₂F₃N₂
  • Molecular Weight 216.98
  • Synonym(s) None
  • SMILES FC(C1=NC(Cl)=NC=C1Cl)(F)F

Description

2,5-Dichloro-4-(trifluoromethyl)pyrimidine features a highly electron-deficient pyrimidine core flanked by two chlorine atoms and a trifluoromethyl group, enabling robust coupling reactions under standard conditions. This bench-stable heterocycle integrates efficiently into pharmaceutical scaffolds and serves as a key building block for agrochemicals and advanced materials.

Application

2,5-Dichloro-4-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its electrophilic C2 and C5 positions facilitate nucleophilic substitution under mild conditions, offering high functional group tolerance and compatibility with diverse coupling partners. Bench-stable and readily purified, it functions efficiently in late-stage diversification strategies for drug discovery and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H318-H410
Precautionary Statements : P264-P270-P273-P280-P305+P351+P338-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.8022
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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