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Structure of 799814-32-7
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2-(Difluoromethyl)benzoic acid features a difluoromethyl group ortho to the carboxylic acid, imparting enhanced metabolic stability and modulated lipophilicity. This electronic and steric profile improves membrane permeability while resisting oxidative degradation. The compound serves as a key building block in medicinal chemistry for bioactive molecule design.
2-(Difluoromethyl)benzoic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a difluoromethyl group—a metabolically stable bioisostere of aldehyde and hydroxymethyl functionalities—into diverse molecular architectures. Its carboxylic acid functionality facilitates direct derivatization or coupling reactions, while the ortho-difluoromethyl substituent imparts enhanced lipophilicity and metabolic resistance. The compound exhibits good bench stability and is compatible with standard synthetic workflows, making it well-suited for the development of functionalized heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: