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Structure of 80194-68-9
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This trifluoromethyl-substituted pyridinecarboxylic acid features a chlorine atom at the 3-position and a strongly electron-withdrawing trifluoromethyl group, enhancing electrophilicity for cross-coupling reactions. The carboxylic acid moiety enables direct derivatization or metal complexation. This scaffold offers high stability under standard conditions and facilitates incorporation into bioactive molecules and functional materials.
3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group and a chloropyridine scaffold into target molecules. Its carboxylic acid functionality facilitates amide bond formation, esterification, and coupling reactions with amines or alcohols under standard conditions. The molecule exhibits good bench stability, moderate solubility in organic solvents, and functional group tolerance, making it suitable for use in multi-step syntheses of heterocyclic APIs and advanced intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: