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Structure of 80253-38-9
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Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride features a sterically hindered quaternary carbon center paired with a protonated primary amine, enabling robust salt formation. This bench-stable derivative delivers enhanced solubility in polar solvents while maintaining compatibility with amine-directed transformations. The ethyl ester moiety supports facile downstream derivatization in synthetic sequences.
Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of sterically hindered amino acid analogs and heterocyclic scaffolds. Its tertiary α-carbon enhances stability and reduces racemization risk during peptide coupling. The amine functionality readily participates in acylation, alkylation, and reductive amination reactions, while the ethyl ester permits selective hydrolysis or transformation under mild conditions. This compound facilitates efficient access to complex molecular architectures with minimal purification challenges.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: