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CS-W001157 4
Total: USD 88.00

Propane-2-sulfonamide

  • CAS No. 81363-76-0

  • Cat. No. CS-W005008
  • Purity≥98%
  • MDL No.MFCD03550610

*For research and further manufacturing use only, not for direct human use.

Propane-2-sulfonamide|CS-W005008

Structure of 81363-76-0

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General Information

  • CAS No. 81363-76-0
  • Cat. No. CS-W005008
  • Purity ≥98%
  • MDL No. MFCD03550610
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉NO₂S
  • Molecular Weight 123.17
  • Synonym(s) Propan-2-sulfonamid
  • SMILES CC(S(=O)(N)=O)C

Description

Propane-2-sulfonamide delivers a robust sulfonamide functionality with enhanced solubility and stability in aqueous and organic media. This bench-stable reagent features a sterically hindered amide group that resists hydrolysis, enabling reliable use in synthetic transformations requiring prolonged reaction times or elevated temperatures.

Application

Propane-2-sulfonamide serves as a stable, bench-ready sulfonamide building block for medicinal chemistry and catalytic synthesis. Its tertiary sulfonamide functionality exhibits excellent functional group tolerance and compatibility with standard coupling protocols. The molecule facilitates the construction of bioactive heterocycles and acts as a versatile scaffold in the development of kinase inhibitors and other pharmaceutical candidates.

Synthesis

  • Route1
    • null|null
      10147-37-2
    • ~81%
    • In-stock
      Propane-2-sulfonamide|CS-W005008
      81363-76-0

    References

    • MERCK SHARP and DOHME LTD. Patent: EP514133 A1, 1992 ; EP 0514133 A1
  • Route2
    • null|null
      10147-37-2
    • null|null
      7664-41-7
    • ~84%
    • In-stock
      Propane-2-sulfonamide|CS-W005008
      81363-76-0

    References

    • LABORATOIRES SERONO SA Patent: WO2008/101979 A1, 2008 ; Location in patent: Page/Page column 87-88 ;
  • Route3
    • null|null
      256532-43-1
    • ~97%
    • In-stock
      Propane-2-sulfonamide|CS-W005008
      81363-76-0

    References

    • Johnson II, David C.; Widlanski, Theodore S. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8483 - 8487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -0.3167
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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