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CS-W001157 4
Total: USD 88.00

2-Chloro-4-(trifluoromethyl)benzaldehyde

  • CAS No. 82096-91-1

  • Cat. No. CS-W005562
  • Purity≥97%
  • MDL No.MFCD04112538
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-(trifluoromethyl)benzaldehyde|CS-W005562

Structure of 82096-91-1

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Description

2-Chloro-4-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination delivers high reactivity in nucleophilic addition and coupling reactions, particularly in pharmaceutical synthesis and agrochemical development under standard conditions.

Application

2-Chloro-4-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via Ullmann or Suzuki coupling reactions. Its electron-withdrawing trifluoromethyl and chloro substituents enhance reactivity in nucleophilic aromatic substitution and facilitate downstream functionalization. The aldehyde group provides a direct handle for imine formation, reductive amination, and conjugate addition, offering high synthetic flexibility. Bench-stable and readily purified by crystallization, it functions reliably in multi-step syntheses requiring robust functional group tolerance.

General Information

  • CAS No. 82096-91-1
  • Cat. No. CS-W005562
  • Purity ≥97%
  • MDL No. MFCD04112538
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClF₃O
  • Molecular Weight 208.57
  • Synonym(s) 2-Chloro-4-Trifluoromethylbenzaldehyde
  • SMILES FC(F)(F)C1=CC(Cl)=C(C=O)C=C1

Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.1713
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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