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Structure of 82096-91-1
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2-Chloro-4-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination delivers high reactivity in nucleophilic addition and coupling reactions, particularly in pharmaceutical synthesis and agrochemical development under standard conditions.
2-Chloro-4-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via Ullmann or Suzuki coupling reactions. Its electron-withdrawing trifluoromethyl and chloro substituents enhance reactivity in nucleophilic aromatic substitution and facilitate downstream functionalization. The aldehyde group provides a direct handle for imine formation, reductive amination, and conjugate addition, offering high synthetic flexibility. Bench-stable and readily purified by crystallization, it functions reliably in multi-step syntheses requiring robust functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: