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Structure of 23228-45-7
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2-Chloro-4-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group enhancing electron-withdrawal and metabolic stability. This robust carboxylic acid derivative integrates readily into bioactive scaffolds, offering high functional group tolerance and compatibility with diverse coupling reactions under standard conditions.
2-Chloro-4-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient functionalization via electrophilic substitution and coupling reactions. Its electron-withdrawing trifluoromethyl and chloro groups enhance reactivity in Suzuki-Miyaura and Ullmann couplings, while the carboxylic acid functionality allows for direct derivatization into amides, esters, or activated acyl intermediates. The compound exhibits excellent bench stability and facilitates purification by recrystallization or column chromatography, making it well-suited for scale-up and multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: